Monday, July 29, 2013 —
“And the chitosan itself can be absorbed by the body, so there are no long term health effects.”
In tests using diabetic laboratory mice, the researchers found the sponge matrix was effective at reducing blood sugar for up to 48 hours. However, the researchers published a separate “smart system” for insulin delivery in May that maintained normal blood sugar levels for 10 days.
“But we learned a lot from the promising ‘sponge’ research and will further optimize it. Meanwhile, we are already exploring applications to combat cancer,” Gu says.
The paper, “Glucose-Responsive Microgels Integrated with Enzyme Nanocapsules for Closed-Loop Insulin Delivery,” is published online in ACS Nano. The research was supported by a grant from the Leona M. and Harry B. Helmsley Charitable Trust Foundation, and a gift from the Tayebati Family Foundation.