The Stanly News and Press (Albemarle, NC)

State & National News

July 11, 2013

Researchers Perform DNA Computation in Living Cells

Thursday, July 11, 2013 — Chemists from North Carolina State University have performed a DNA-based logic-gate operation within a human cell. The research may pave the way to more complicated computations in live cells, as well as new methods of disease detection and treatment.

 

Logic gates are the means by which computers “compute,” as sets of them are combined in different ways to enable computers to ultimately perform tasks like addition or subtraction. In DNA computing, these gates are created by combining different strands of DNA, rather than a series of transistors. However, thus far DNA computation events have typically taken place in a test tube, rather than in living cells.

 

NC State chemist Alex Deiters and graduate student James Hemphill wanted to see if a DNA-based logic gate could detect the presence of specific microRNAs in human cells. The researchers utilized a DNA-based logic gate known as an “AND” gate that was engineered to respond to the presence of two specific microRNAs – known as miRNA-21 and miRNA-122.

 

Just as computer operations utilize different inputs to create a particular output, the researchers’ DNA-based Boolean logic gate was activated only when both miRNA-21 and miRNA-122 “inputs” were present in cells. If they were present, the gate generated an “output” by releasing a fluorescent molecule.

 

Deiters believes that use of these logic gates could lead to more accurate tests and treatments for human disease, especially cancer.

 

“The fluorescent molecule we used in this logic-gate design could be useful as a marker that identifies a cancer cell,” he says.

“Or, instead of directing the gate to release a fluorescent molecule in the presence of particular microRNAs, we could attach therapeutic agents that are released to treat the disease itself.”

 

Their results appear in the Journal of the American Chemical Society. The research was funded in part by grants from the American Chemical Society and the American Cancer Society.

1
Text Only
State & National News
  • linda-ronstadt.jpg Obama had crush on First Lady of Rock

    Linda Ronstadt remained composed as she walked up to claim her National Medal of Arts at a White House ceremony Monday afternoon.

    July 29, 2014 1 Photo

  • Brother sues W.Va. senator over business loan

    FAIRMONT, W. Va. - U.S. Sen. Joe Manchin's brother claims he's owed $1.7 million that he loaned to keep a family carpet out of bankruptcy in the 1980s.

    July 28, 2014

  • CATS-DOGS281.jpg Where cats are more popular than dogs in the U.S.-and all over the world

    We all know there are only two types of people in the world: cat people and dog people. But data from market research firm Euromonitor suggest that these differences extend beyond individual preferences and to the realm of geopolitics: it turns out there are cat countries and dog countries, too.

    July 28, 2014 1 Photo

  • WORLD NEWS: Fast food comes to standstill in China

    BEIJING - The shortage of meat is the result of China's latest food scandal, in which a Shanghai supplier allegedly tackled the problem of expired meat by putting it in new packaging and shipping it to fast-food restaurants around the country

    July 28, 2014

  • Facebook continues moneymaking trend

    WASHINGTON - Facebook seems to have figured out - for now at least - the holy grail for all media right now: how to make money selling mobile ads.

    July 25, 2014

  • Arizona's prolonged lethal injection is fourth in U.S. this year

    NEW YORK - Arizona's execution of double-murderer Joseph Wood marked the fourth time this year that a state failed to dispatch a convict efficiently, according to the Constitution Project, a bipartisan legal group.

    July 25, 2014

  • N.C. Energy Policy Council Long Range Energy Generation and Renewable Energy Committee to meet

    RALEIGH – The North Carolina Energy Policy Council’s Long Range Energy Generation and Renewable Energy Committee will meet via conference call at 9 a.m. July 31.

    July 24, 2014

  • N.C. State University Turfgrass Field Day set for Aug. 13

    N.C. State University’s annual Turfgrass Field Day will be held in Raleigh at the Lake Wheeler Turfgrass Research Lab, Aug. 13, 8:30 a.m. - 2 p.m. One of the largest events of its kind in the country, the field day offers the industry and general public a chance to view the Turfgrass Program’s ongoing research trials and speak directly with N.C. State faculty and staff.

    July 24, 2014

  • NCSU Study: Urban Heat Boosts Some Pest Populations 200-Fold, Killing Red Maples

                New research from North Carolina State University shows that urban “heat islands” are slowly killing red maples in the southeastern United States. One factor is that researchers have found warmer temperatures increase the number of young produced by the gloomy scale insect – a significant tree pest – by 300 percent, which in turn leads to 200 times more adult gloomy scales on urban trees.

    July 23, 2014

  • An oncologist uses scorpion venom to locate cancer cells

    Olson, a pediatric oncologist and research scientist in Seattle, has developed a compound he calls Tumor Paint. When injected into a cancer patient, it seems to light up all the malignant cells so surgeons can easily locate and excise them.

    July 22, 2014

House Ads
Seasonal Content