Best Bets for NCAA Basketball Picks Against the Spread for Saturday, February 22
Published 8:33 pm Friday, February 21, 2025
The matchups on the Saturday college basketball slate for which we have suggested picks against the spread include the Iowa State Cyclones squaring off against the Houston Cougars at Fertitta Center.
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Today’s NCAA Men’s Basketball Picks ATS
ATS Pick: Iowa State +12.5 vs. Houston
- Matchup: Iowa State Cyclones at Houston Cougars
- Time: 2 p.m. ET
- Date: February 22
- Computer Projection: Houston by 6.7 points (Bet now on BetMGM)
- Spread: Houston (-12.5)
- TV Channel: ESPN
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
ATS Pick: Kentucky +11.5 vs. Alabama
- Matchup: Kentucky Wildcats at Alabama Crimson Tide
- Time: 6 p.m. ET
- Date: February 22
- Computer Projection: Alabama by 5.9 points (Bet now on BetMGM)
- Spread: Alabama (-11.5)
- TV Channel: ESPN
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
ATS Pick: Mississippi Valley State +24.5 vs. Texas Southern
- Matchup: Mississippi Valley State Delta Devils at Texas Southern Tigers
- Time: 6 p.m. ET
- Date: February 22
- Computer Projection: Texas Southern by 19.4 points (Bet now on BetMGM)
- Spread: Texas Southern (-24.5)
- TV Channel: SWAC Digital Network
ATS Pick: Cal Baptist +10.5 vs. Grand Canyon
- Matchup: Cal Baptist Lancers at Grand Canyon Antelopes
- Time: 8 p.m. ET
- Date: February 22
- Computer Projection: Grand Canyon by 5.6 points (Bet now on BetMGM)
- Spread: Grand Canyon (-10.5)
- TV Channel: ESPN+
- Live Stream: Watch this game on ESPN+
ATS Pick: Saint Francis (PA) +1.5 vs. Fairleigh Dickinson
- Matchup: Fairleigh Dickinson Knights at Saint Francis (PA) Red Flash
- Time: 2 p.m. ET
- Date: February 22
- Computer Projection: Saint Francis (PA) by 2.9 points (Bet now on BetMGM)
- Spread: Fairleigh Dickinson (-1.5)
- TV Channel: NEC Front Row
Bet on this or any men’s college basketball matchup at BetMGM.
ATS Pick: Ole Miss +1.5 vs. Vanderbilt
- Matchup: Ole Miss Rebels at Vanderbilt Commodores
- Time: 3:30 p.m. ET
- Date: February 22
- Computer Projection: Ole Miss by 2.2 points (Bet now on BetMGM)
- Spread: Vanderbilt (-1.5)
- TV Channel: SEC Network
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
ATS Pick: Liberty -13.5 vs. Florida International
- Matchup: Florida International Panthers at Liberty Flames
- Time: 2 p.m. ET
- Date: February 22
- Computer Projection: Liberty by 17.1 points (Bet now on BetMGM)
- Spread: Liberty (-13.5)
- TV Channel: ESPN+
- Live Stream: Watch this game on ESPN+
ATS Pick: American -3.5 vs. Boston University
- Matchup: Boston University Terriers at American Eagles
- Time: 4 p.m. ET
- Date: February 22
- Computer Projection: American by 7.1 points (Bet now on BetMGM)
- Spread: American (-3.5)
- TV Channel: ESPN+
- Live Stream: Watch this game on ESPN+
ATS Pick: Delaware State +4.5 vs. South Carolina State
- Matchup: South Carolina State Bulldogs at Delaware State Hornets
- Time: 4 p.m. ET
- Date: February 22
- Computer Projection: South Carolina State by 0.9 points (Bet now on BetMGM)
- Spread: South Carolina State (-4.5)
- TV Channel: ESPN+
- Live Stream: Watch this game on ESPN+
ATS Pick: Tennessee +2.5 vs. Texas A&M
- Matchup: Tennessee Volunteers at Texas A&M Aggies
- Time: 12 p.m. ET
- Date: February 22
- Computer Projection: Tennessee by 1.1 points (Bet now on BetMGM)
- Spread: Texas A&M (-2.5)
- TV Channel: ESPN
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
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